Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Kill Curves versus MIC

Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC.

Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue.

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue Markus Müller, Amparo dela Peña, and Hartmut Derendorf* Health Science Center, Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, and Vienna General Hospital, Division of Clinical Pharmacokinetics, Department of Clinical Pharmacology, School of Medicine, V...

Pharmacokinetics and pharmacodynamics in the development of anti-tuberculosis drugs.

Optimization of dosing strategies and companion drugs prior to Phase III trials is currently a critical obstacle in the development of new anti-tuberculosis drugs. Pharmacokinetic-pharmacodynamic (PK-PD) methods have assumed an important role in improving the efficiency of this process across the pharmaceutical industry and in other areas of anti-infective therapy. Information gained using PK-P...

Pharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats

The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...

Pharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats

The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...